for the treatment of hypertension. Irbesartan was developed by Sanofi Research avapro and toprol part of sanofi-aventis). It is jointly marketed by sanofi-aventis and Bristol-Myers Squibb under the trade names to irbesartan preparations, including CoAprovel, Karvezide, avapro and toprol and Avapro HCT.[edit] References^.

irbesartan in patients with nephropathy due to type 2 diabetes.". N Engl J Med 345 (12): avapro and toprol PMID 11565517.^ Rossi S, editor. Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006. ISBN 0-9757919-2-3 IrbesartanFrom Wikipedia, the free avapro and toprol from Avapro)Jump to: navigation, searchIrbesartanSystematic (IUPAC) name2-butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-oneIdentifiersCAS number 138402-11-6ATC code C09CA04PubChem 3749DrugBank APRD00413Chemical dataFormula C25H28N6OMol. avapro and toprol 428.53SMILES eMolecules & PubChemPharmacokinetic dataBioavailability 60–80%Metabolism Hepatic (CYP2C9)Half life 11–15 hoursExcretion Renal 20%, faecal 65%Therapeutic considerationsLicence data EU, USPregnancy cat. D (Au)Legal status S4 (Au), POM avapro and toprol ?-only (U.S.)Routes OralIrbesartan (INN) (pronounced avapro and toprol is an avapro and toprol II receptor antagonists, irbesartan is indicated for the reduction of renal disease.

a combination formulation with a low dose thiazide diuretic, invariably hydrochlorothiazide, to achieve an additive.